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Front Neuroendocrinol. 2012 Oct;33(4):403-11. doi: 10.1016/j.yfrne.2012.08.005. Epub 2012 Sep 5.

The cerebellum as a target for estrogen action.

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1
Department of Neuroscience and Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, United States.

Abstract

This review focuses on the effects of estrogens upon the cerebellum, a brain region long ignored as a site of estrogen action. Highlighted are the diverse effects of estradiol within the cerebellum, emphasizing the importance of estradiol signaling in cerebellar development, modulation of synaptic neurotransmission in the adult, and the potential influence of estrogens on various health and disease states. We also provide new data, consistent with previous studies, in which locally synthesized estradiol modulates cerebellar glutamatergic neurotransmission, providing one underlying mechanism by which the actions of estradiol can affect this brain region.

PMID:
22975197
PMCID:
PMC3496070
DOI:
10.1016/j.yfrne.2012.08.005
[Indexed for MEDLINE]
Free PMC Article
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