Format

Send to

Choose Destination
Curr Biol. 2012 Sep 11;22(17):R762-71. doi: 10.1016/j.cub.2012.06.065.

Cancer in light of experimental evolution.

Author information

1
Institute for Evolutionary Biology and Environmental Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. kathleen.sprouffske@ieu.uzh.ch

Abstract

Cancer initiation, progression, and the emergence of therapeutic resistance are evolutionary phenomena of clonal somatic cell populations. Studies in microbial experimental evolution and the theoretical work inspired by such studies are yielding deep insights into the evolutionary dynamics of clonal populations, yet there has been little explicit consideration of the relevance of this rapidly growing field to cancer biology. Here, we examine how the understanding of mutation, selection, and spatial structure in clonal populations that is emerging from experimental evolution may be applicable to cancer. Along the way, we discuss some significant ways in which cancer differs from the model systems used in experimental evolution. Despite these differences, we argue that enhanced prediction and control of cancer may be possible using ideas developed in the context of experimental evolution, and we point out some prospects for future research at the interface between these traditionally separate areas.

PMID:
22975007
PMCID:
PMC3457634
DOI:
10.1016/j.cub.2012.06.065
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center