Format

Send to

Choose Destination
See comment in PubMed Commons below
Genes Dev. 2012 Oct 1;26(19):2144-53. doi: 10.1101/gad.192294.112. Epub 2012 Sep 12.

Age-associated inflammation inhibits epidermal stem cell function.

Author information

1
Centre for Genomic Regulation, Barcelona 08003, Spain.

Abstract

Altered stem cell homeostasis is linked to organismal aging. However, the mechanisms involved remain poorly understood. Here we report novel alterations in hair follicle stem cells during skin aging, including increased numbers, decreased function, and an inability to tolerate stress. Performing high-throughput RNA sequencing on aging stem cells, cytokine arrays, and functional assays, we identify an age-associated imbalance in epidermal Jak-Stat signaling that inhibits stem cell function. Collectively, this study reveals a role for the aging epidermis in the disruption of cytokine and stem cell homeostasis, suggesting that stem cell decline during aging may be part of broader tumor-suppressive mechanisms.

PMID:
22972935
PMCID:
PMC3465736
DOI:
10.1101/gad.192294.112
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center