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Biosci Biotechnol Biochem. 2012;76(9):1633-8. Epub 2012 Sep 7.

Anti-influenza virus effects of elderberry juice and its fractions.

Author information

1
Research and Development Division, Kikkoman Corporation, 399 Noda, Noda, Chiba 278-0037, Japan. ekinoshita@mail.kikkoman.co.jp

Abstract

Elderberry (Sambucus nigra L.) has traditionally been used for treating influenza and colds. We evaluated the antiviral effect of concentrated juice of elderberry (CJ-E) on the human influenza A virus (IFV). CJ-E had a relatively strong effect on IFV-infected mice, although its anti-IFV activity was weak in a cell culture system. The in vivo anti-IFV activities of the fractions were determined after separating CJ-E by ultrafiltration and anion-exchange chromatography. Oral administration of the high-molecular-weight fractions of CJ-E to IFV-infected mice suppressed viral replication in the bronchoalveolar lavage fluids (BALFs), and increased the level of the IFV-specific neutralizing antibody in the serum, as well as the level of secretory IgA in BALFs and feces. Fr. II from high-molecular-weight fraction HM, which contained acidic polysaccharides, showed relatively strong defense against IFV infection. We conclude that CJ-E had a beneficial effect by the stimulating immune response and preventing viral infection.

PMID:
22972323
DOI:
10.1271/bbb.120112
[Indexed for MEDLINE]
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