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Nature. 2012 Sep 13;489(7415):250-6. doi: 10.1038/nature11553.

Genomic approaches to studying the human microbiota.

Author information

1
The Genome Institute, Washington University, St. Louis, Missouri 63108, USA. gweinsto@genome.wustl.edu

Abstract

The human body is colonized by a vast array of microbes, which form communities of bacteria, viruses and microbial eukaryotes that are specific to each anatomical environment. Every community must be studied as a whole because many organisms have never been cultured independently, and this poses formidable challenges. The advent of next-generation DNA sequencing has allowed more sophisticated analysis and sampling of these complex systems by culture-independent methods. These methods are revealing differences in community structure between anatomical sites, between individuals, and between healthy and diseased states, and are transforming our view of human biology.

PMID:
22972298
PMCID:
PMC3665339
DOI:
10.1038/nature11553
[Indexed for MEDLINE]
Free PMC Article

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