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Cell Mol Life Sci. 2012 Nov;69(21):3533-41. doi: 10.1007/s00018-012-1124-0. Epub 2012 Sep 13.

MicroRNA-29 in the adaptive immune system: setting the threshold.

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1
Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium.

Abstract

Recent research into the role of microRNA (miR) in the immune system has identified the miR-29 family as critical regulators of key processes in adaptive immunity. The miR-29 family consists of four members with shared regulatory capacity, namely miR-29a, miR-29b-1, miR-29b-2 and miR-29c. Being expressed in both T and B cells, as well as the main accessory cell types of thymic epithelium and dendritic cells, the miR-29 family has been identified as a putative regulator of immunity due to the predicted suppression of key immunological pathways. The generation of a series of in vivo molecular tools targeting the miR-29 family has identified the critical role of these miR in setting the molecular threshold for three central events in adaptive immunity: (1) control over thymic production of T cells by modulating the threshold for infection-associated thymic involution, (2) creating a neutral threshold for T cell polarization following activation, and (3) setting the threshold for B cell oncogenic transformation. These results identify the miR-29 family as potent immune modulators which have already been exploited through the evolution of a viral mimic and could potentially be exploited further for therapeutic intervention.

PMID:
22971773
DOI:
10.1007/s00018-012-1124-0
[Indexed for MEDLINE]

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