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Front Syst Neurosci. 2012 Sep 3;6:63. doi: 10.3389/fnsys.2012.00063. eCollection 2012.

Classification of ADHD children through multimodal magnetic resonance imaging.

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Neural Imaging Computation and Analysis Group, State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences Beijing, China.


Attention deficit/hyperactivity disorder (ADHD) is one of the most common diseases in school-age children. To date, the diagnosis of ADHD is mainly subjective and studies of objective diagnostic method are of great importance. Although many efforts have been made recently to investigate the use of structural and functional brain images for the diagnosis purpose, few of them are related to ADHD. In this paper, we introduce an automatic classification framework based on brain imaging features of ADHD patients and present in detail the feature extraction, feature selection, and classifier training methods. The effects of using different features are compared against each other. In addition, we integrate multimodal image features using multi-kernel learning (MKL). The performance of our framework has been validated in the ADHD-200 Global Competition, which is a world-wide classification contest on the ADHD-200 datasets. In this competition, our classification framework using features of resting-state functional connectivity (FC) was ranked the 6th out of 21 participants under the competition scoring policy and performed the best in terms of sensitivity and J-statistic.


ADHD-200 competition; attention deficit/hyperactivity disorder; multi-kernel learning; resting-state functional connectivity; support vector machine

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