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Mult Scler. 2013 Apr;19(5):567-76. doi: 10.1177/1352458512459289. Epub 2012 Sep 11.

Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis.

Author information

1
Buffalo Neuroimaging Analysis Center, University at Buffalo, USA.

Abstract

OBJECTIVE:

The objective of this paper is to assess abnormal phase values, indicative of increased iron content, using susceptibility-weighted imaging (SWI)-filtered phase of the subcortical deep gray matter (SDGM) in adolescent multiple sclerosis (MS) and other neurological disorders (OND) patients, and in healthy controls (HC).

METHODS:

Twenty adolescent MS and eight adolescent OND patients and 21 age- and sex-matched HC were scanned on a 3T GE scanner. Mean phase of abnormal phase tissue (MP-APT), MP-APT volume, normal phase tissue volume (NPTV) and normalized volume measurements were obtained for total SDGM, as well as specific structures separately.

RESULTS:

Significantly increased MP-APT (28.2%, p<.001) and MP-APT volume (82.7%, p<.001), and decreased NPTV (-23.3%, p<.001) and normalized volume (-15.5%, p<.001) in the pulvinar nucleus of the thalamus was found in MS patients compared to HC. MP-APT in MS patients was also increased in total SDGM (p=.012) and thalamus (p=.044). Compared to OND patients, MS patients had increased MP-APT volume in the pulvinar nucleus of the thalamus (p=.044) and caudate (p=.045). Increased MP-APT of the SDGM structures were associated with increased T2 and T1 lesion burden and brain atrophy in MS patients.

CONCLUSION:

Adolescent MS patients showed increased iron content in the SDGM compared to OND patients and HC.

PMID:
22968543
DOI:
10.1177/1352458512459289
[Indexed for MEDLINE]

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