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Neurotoxicology. 2012 Dec;33(6):1434-5. doi: 10.1016/j.neuro.2012.07.009. Epub 2012 Aug 8.

Is retinoic acid-related orphan receptor-alpha (RORA) a target for gene-environment interactions contributing to autism?

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  • 1Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.


It is becoming increasingly clear that gene-environment interactions are risk factors for autism. However, there is limited information regarding the susceptibility of specific autism candidate genes to dysregulation by environmental factors, and even less information on the types of environmental agents that may lead to increased risk for autism. Based on our published studies, I propose that the demonstrated responsiveness of RORA to sex hormones makes it a prime target for disruption by endocrine disrupting compounds.

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