Format

Send to

Choose Destination
See comment in PubMed Commons below
Brief Bioinform. 2012 Nov;13(6):728-42. doi: 10.1093/bib/bbs039. Epub 2012 Sep 9.

Current opportunities and challenges in microbial metagenome analysis--a bioinformatic perspective.

Author information

1
Max Planck Institute for Marine Microbiology, Bremen, Germany.

Abstract

Metagenomics has become an indispensable tool for studying the diversity and metabolic potential of environmental microbes, whose bulk is as yet non-cultivable. Continual progress in next-generation sequencing allows for generating increasingly large metagenomes and studying multiple metagenomes over time or space. Recently, a new type of holistic ecosystem study has emerged that seeks to combine metagenomics with biodiversity, meta-expression and contextual data. Such 'ecosystems biology' approaches bear the potential to not only advance our understanding of environmental microbes to a new level but also impose challenges due to increasing data complexities, in particular with respect to bioinformatic post-processing. This mini review aims to address selected opportunities and challenges of modern metagenomics from a bioinformatics perspective and hopefully will serve as a useful resource for microbial ecologists and bioinformaticians alike.

PMID:
22966151
PMCID:
PMC3504927
DOI:
10.1093/bib/bbs039
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Support Center