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Oncology. 2012;83(5):292-9. doi: 10.1159/000342376. Epub 2012 Sep 5.

Comparison of two inflammation-based prognostic scores in patients with unresectable advanced gastric cancer.

Author information

1
Department of Medical Oncology and Hematology, Kyung Hee Medical Center, Kyung Hee University, Seoul, Korea.

Abstract

OBJECTIVES:

The objective of this study was to compare the usefulness of two inflammation-based prognostic scores, neutrophil to lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS), assessed at diagnosis in stage IV advanced gastric cancer (AGC).

METHODS:

We retrospectively reviewed the medical records of 104 patients with newly diagnosed metastatic AGC treated with palliative chemotherapy.

RESULTS:

In the univariate analysis, the following variables were associated with shorter overall survival (OS): poor or undifferentiated histology (p = 0.013), more than 1 metastasis (p = 0.004), the presence of lymph node metastasis (p = 0.003), the presence of bone metastasis (p = 0.019), a lower albumin level (p < 0.001), elevated C-reactive protein (p < 0.001), a high absolute neutrophil count (p = 0.016), NLR ≥3 (p < 0.001) and higher mGPS (p < 0.001 and p = 0.007, respectively). In the multivariate analysis, high NLR and mGPS were independent prognostic factors for shorter OS (p = 0.037, p < 0.001 and p = 0.010, respectively), along with lymph node metastasis (p = 0.005) and histological subtype (p = 0.048).

CONCLUSION:

This study suggests that the inflammatory markers, NLR and mGPS, are independent prognostic factors for OS in patients with unresectable AGC treated with palliative chemotherapy.

PMID:
22964877
DOI:
10.1159/000342376
[Indexed for MEDLINE]

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