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Pediatr Neurol. 2012 Oct;47(4):299-302. doi: 10.1016/j.pediatrneurol.2012.06.015.

Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease.

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Section of Neurology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.


Krabbe disease may present during infancy, late infancy, or adulthood. Earlier-onset disease is associated with shorter survival times. We present a case of infantile onset Krabbe disease with prolonged survival, initial intracranial optic nerves and optic chiasm hypertrophy, and serial changes on cranial magnetic resonance imaging and magnetic resonance spectroscopy.

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