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Int J Tuberc Lung Dis. 2012 Nov;16(11):1468-70. doi: 10.5588/ijtld.12.0127. Epub 2012 Sep 7.

Performance of the Xpert® MTB/RIF assay in an active case-finding strategy: a pilot study from Tanzania.

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National Institute for Medical Research, Mbeya Medical Research Programme, Mbeya, Tanzania.


In this pilot study, we evaluated the Xpert® MTB/RIF assay in an active case-finding strategy, using two spot sputum samples collected within a 1-hour interval from household contacts of smear-positive TB index cases. Tuberculosis (TB) confirmed by culture served as the reference standard. Among 219 enrolled contacts, the yield of active TB was 2.3%. While the sensitivity of smear microscopy was 60% (95%CI 14.7-94.7), Xpert MTB/RIF achieved a sensitivity of 100% (95%CI 47.81-100.0). All culture-confirmed cases tested positive by Xpert MTB/RIF on the first submitted sample, suggesting that the evaluation of only one sample could be sufficient for TB diagnosis in this context.

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