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Acta Paediatr. 2012 Nov;101(11):1114-20. doi: 10.1111/j.1651-2227.2012.02825.x. Epub 2012 Sep 11.

Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic predisposition?

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Division of Asthma, Allergy and Lung Biology, the MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, UK.


A systematic literature review has been undertaken. Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) in infancy is associated with chronic respiratory morbidity. Premorbid abnormal lung function may predispose to RVS LRTI in prematurely born infants.


  Single-nucleotide polymorphisms in genes coding for IL-8, IL-19, IL-20, IL-13 mannose-binding lectin, IFNG and a RANTES polymorphism have been associated with subsequent wheeze following RSV LRTI in term-born infants.

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