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Acta Ophthalmol. 2013 Dec;91(8):694-700. doi: 10.1111/j.1755-3768.2012.02526.x. Epub 2012 Sep 11.

IgG4-related orbital disease: a meta-analysis and review.

Author information

1
South Australian Institute of Ophthalmology and Department of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South AustraliaInstitute of Medical and Veterinary Science, Department of Surgical Pathology, Adelaide, South Australia.

Abstract

IgG4-related orbital disease (IgG4-ROD) is a recently described condition that may account for a significant proportion of idiopathic lymphoplasmacytic or sclerotic orbital lesions. This study is the first meta-analysis of published cases and reveals several differences between IgG4-related disease affecting the orbit and that affecting the pancreas. IgG4-ROD affects a slightly younger group of patients, affects men and women approximately equally, is commonly associated with salivary gland lesions, is associated with a relatively higher serum IgG4 and may confer an increased risk of non-Hodgkin Lymphoma. Its pathogenesis may involve an immune response to antigen exposure in the upper aerodigestive tract.

KEYWORDS:

IgG4; IgG4-related disease; IgG4-related orbital disease; dacryoadenitis; orbital; review

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