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Brain. 2012 Sep;135(Pt 9):2585-612. doi: 10.1093/brain/aws225.

Neurological perspectives on voltage-gated sodium channels.

Author information

1
Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK. n.eijkelkamp@ucl.ac.uk

Abstract

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors.

PMID:
22961543
PMCID:
PMC3437034
DOI:
10.1093/brain/aws225
[Indexed for MEDLINE]
Free PMC Article

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