Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Bioinform Res Appl. 2012;8(3-4):192-209. doi: 10.1504/IJBRA.2012.048965.

Identifying cancer highly-expressed membrane receptors for targeted drug delivery.

Author information

1
Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu, Taiwan. loveariddle.bi96g@g2.nctu.edu.tw

Abstract

Currently, the accompanying side effects of anti-cancer drugs owing to incorrect delivery to normal tissues should be reduced. We present a database (MRTDD) with identified cancer highly-expressed membrane receptors (CHMRs) which can be used in targeted drug delivery. To evaluate the probability of occurrence of incorrect delivery, we calculate tissue index for each CHMR and expect to identify good candidates. The information provided includes: (1) genomic annotations; (2) gene expression profiles of membrane receptors in cancer tissue vs. corresponding normal tissue, normal tissues of body and cancer cell-lines; (3) available antibody services of manufacturers. MRTDD is available at http://mrtdd.mbc.nctu.edu.tw/.

PMID:
22961451
DOI:
10.1504/IJBRA.2012.048965
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center