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Nat Genet. 2012 Oct;44(10):1137-41. doi: 10.1038/ng.2395. Epub 2012 Sep 9.

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

Collaborators (208)

Alexander G, Bathgate A, Burroughs A, Cordell H, Davies M, Donaldson P, Heneghan M, Jones D, Mells G, Neuberger J, Thain C, Sandford R, Street B, Lye C, Lai C, Yapp T, Sturgess R, Healey C, Czajkowski M, Peter S, Thornton J, Mann S, Kapur K, Marley R, Foster G, Ramage J, Harvey R, MacDougall N, Shorrock CJ, Lipscomb G, Southern P, Parnell N, Tibble J, Gorard D, Mells G, Dawwas M, Aspinall R, Dolwani S, Foxton M, Mitchison H, Gooding I, Patel M, Ede R, Austin A, Dawood R, Sayer J, Hovell C, Fisher N, Carter M, Koss K, Piotrowicz A, Banait D, Neal D, Lim G, Ala A, Saeed A, Brown J, Thomas S, Wilkinson M, Ridpath J, Ngatchu T, Levi S, Ransford R, Dickinson R, Shidrawi R, Abouda G, Rees I, Salam I, Ali F, Narain M, Brown A, Khakoo S, Williams S, Williams M, Chilton A, Westbrook R, Heneghan M, Rodrigues C, Davies M, Aldersley M, Millson C, Sen S, Bird G, Smith L, Yoong K, Rajendran N, Mathew R, MacFaul G, Shah A, Evans C, Saha S, Bramley P, Fraser A, Mills P, Shallcross T, de Las Heras D, Sheen C, Crofton R, Prach A, Shepherd A, Kennedy H, Rushbrook S, Przemioslo R, McDonald C, Javaid B, Chaudhury B, Metcalf J, Ramanaden D, Gasem J, Evans R, Shmueli U, Naqvi A, Collier J, Klass H, Ninkovic M, Cramp M, Goggin P, Hoeroldt B, Lipscomb G, Williams E, Hussaini H, Devon R, Ayres R, Makanyanga J, Burroughs A, Richardson P, Lombard M, Robertson D, Farrant M, Tanner A, Singhal S, Babu S, Gleeson D, Butterworth J, George K, Curtis H, McNair A, Nasr I, Douglas A, Shearman J, Nash K, Wright M, Bray G, Mclindon J, Das D, Whatley G, Lean S, Sivaramakrishnan N, Ducker S, Jones D, Preston D, Douds A, Brookes M, Wong VS, Pereira S, Carbone M, Neuberger J, Watts G, Gordon F, Unitt E, Grant A, Cox M, Whalley S, Fraser J, Li A, Bell A, Gordon H, Singhal A, Ahmad I, NHS L, Ang Y, Gotto J, Turnbull A, Anderson CA, Barrett JC, Floyd JA, S C, McGinnis R, Soranzo N, Sambrook J, Stephens J, Ouwehand WH, McArdle WL, Ring SM, Strachan DP, Alexander G, Barrett JC, Bulik CM, Conlon PJ, Dominiczak A, Duncanson A, Hill A, Lord G, Maxwell AP, Morgan L, Peltonen L, N R, Sheerin N, Soranzo N, Vannberg FO, Barrett JC, Concannon P, Gray E, Hunt SE, Langford C, Potter S, Rich S, Simpkin D.

Author information

1
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

Abstract

We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium and 8,514 UK population controls across 196,524 variants within 186 known autoimmune risk loci. We identified 3 loci newly associated with PBC (at P<5×10(-8)), increasing the number of known susceptibility loci to 25. The most associated variant at 19p12 is a low-frequency nonsynonymous SNP in TYK2, further implicating JAK-STAT and cytokine signaling in disease pathogenesis. An additional five loci contained nonsynonymous variants in high linkage disequilibrium (LD; r2>0.8) with the most associated variant at the locus. We found multiple independent common, low-frequency and rare variant association signals at five loci. Of the 26 independent non-human leukocyte antigen (HLA) signals tagged on the Immunochip, 15 have SNPs in B-lymphoblastoid open chromatin regions in high LD (r2>0.8) with the most associated variant. This study shows how data from dense fine-mapping arrays coupled with functional genomic data can be used to identify candidate causal variants for functional follow-up.

PMID:
22961000
PMCID:
PMC3459817
DOI:
10.1038/ng.2395
[Indexed for MEDLINE]
Free PMC Article

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