Send to

Choose Destination
Exp Gerontol. 2012 Dec;47(12):936-9. doi: 10.1016/j.exger.2012.08.010. Epub 2012 Aug 31.

Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome.

Author information

Division of Anti-Ageing and Longevity Sciences, Department of Medical Technology, Toin University of Yokohama, Japan.


Minor inflammation-driven aging (inflammaging) has been proposed to explain human aging mechanism. To study the inflammatory condition associated with normal human aging, highly sensitive CRP (hsCRP) was examined in the sera collected from 217 healthy Japanese individuals aged between 1 and 100years and 41 mutation-proven Japanese Werner syndrome (WS) patients. The serum hsCRP was assayed by ELISA. The serum hsCRP level increased significantly (p<0.001) with normal aging from both sexes. The serum hsCRP was significantly elevated in WS (mean±SE: 11.0±1.6μg/ml) compared with age-matched normal population (1.3±0.3μg/ml, p<0.001) and normal elderly population ages between 71 and 100years (4.2±0.7μg/ml, p<0.001). Both normal aging and WS were associated with minor inflammation that can be evaluated by serum hsCRP. WS may be a good candidate to study inflammaging.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center