Format

Send to

Choose Destination
Cogn Behav Neurol. 2012 Sep;25(3):107-14. doi: 10.1097/WNN.0b013e31826df7fd.

Impact of armodafinil on cognition in multiple sclerosis: a randomized, double-blind crossover pilot study.

Author information

1
Department of Psychology, University of Missouri-Kansas City, Kansas City, MO 64110, USA. brucejm@umkc.edu

Abstract

OBJECTIVE:

Examine the efficacy of armodafinil in improving cognition in patients with multiple sclerosis (MS).

BACKGROUND:

Many patients with MS experience cognitive difficulties. Armodafinil has shown promise as a cognitive enhancer in other patient populations. No studies have examined whether armodafinil improves cognition in patients with MS.

METHODS:

We conducted a double-blind, placebo-controlled, crossover study testing the efficacy of armodafinil in reducing cognitive problems in patients with MS. We randomized 17 patients to receive a dose of lactose placebo about 2 hours before they underwent a neuropsychological testing session. After a week-long washout period, we gave them a single 250-mg dose of armodafinil about 2 hours before testing them a second time. We randomized another 16 patients to receive the active drug first, then the placebo. We excluded 3 of the participants before analyzing the data.

RESULTS:

After correcting for multiple comparisons of the 8 neuropsychological dependent measures, we found that the patients had significantly improved delayed memory on a list-learning task after they took armodafinil (P = 0.0005), but no improvement on measures of executive function, visual memory, processing speed, or self-reported fatigue.

CONCLUSIONS:

Results provide preliminary evidence that armodafinil may improve delayed verbal recall in patients with MS. A larger trial showing enhanced memory among patients taking long-term armodafinil could serve as a foundation for its possible clinical use as a memory enhancer in patients with MS.

PMID:
22960434
DOI:
10.1097/WNN.0b013e31826df7fd
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center