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J Ethnopharmacol. 2012 Oct 31;144(1):67-72. doi: 10.1016/j.jep.2012.08.027. Epub 2012 Aug 30.

Pharmacological evaluation of sedative-hypnotic activity and gastro-intestinal toxicity of Rhizoma Paridis saponins.

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1
Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Weijin Road, Tianjin 300072, China.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Rhizoma Paridis saponins (RPS) have been well studied for antimicrobial, anti-hemorrhagic, and anticancer effects. However, scientific information on RPS regarding the toxic and neuropharmacological effects is limited. In this study, the acute oral toxicity, sedative-hypnotic activity and gastro-intestinal toxicity of RPS were investigated.

MATERIALS AND METHODS:

The acute toxicity was carried out by administering single doses (800-5000 mg/kg) of RPS to adult mice. Rotarod test and sodium pentobarbital-induced hypnosis activity were used to evaluate the neuropharmacological effects on mice. Gastric emptying and intestinal transit were used to investigate the gastric-intestinal system effects.

RESULTS:

A single oral administration of RPS dose-dependently caused adverse effects on the general behavior and mortality rate of mice. LD(50) value of oral acute toxicity was 2182.4 mg/kg, with 95% confidence limit of 1718.4-2807.8 mg/kg. In the test of sleeping mice, RPS acted in synergy with sodium pentobarbital at doses 250 and 500 mg/kg while motor coordination was not influenced within 120 min after treatment with RPS. Regarding the gastric-intestinal toxicity, RPS (100, 250, and 500 mg/kg) significantly inhibited gastric emptying but did not affect the intestinal transit.

CONCLUSIONS:

RPS, which is a hypotoxic anticancer drug, possesses the sedative-hypnotic activity and gastric stimulus side effect.

PMID:
22960390
DOI:
10.1016/j.jep.2012.08.027
[Indexed for MEDLINE]
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