Format

Send to

Choose Destination
J Med Chem. 1990 Jan;33(1):52-60.

Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids.

Author information

1
Hoechst AG, Frankfurt/M, West Germany.

Abstract

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized. Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b) on HMG-CoA reductase, both in vitro and in vivo. First clinical trials with 2i (HR 780) are in preparation.

PMID:
2296036
DOI:
10.1021/jm00163a010
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center