Format

Send to

Choose Destination
J Med Chem. 1990 Jan;33(1):49-52.

5-[(Aminoalkyl)amino]imidazo[4,5,1-de]acridin-6-ones as a novel class of antineoplastic agents. Synthesis and biological activity.

Author information

1
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.

Abstract

A new class of antineoplastic agents, the 5-substituted imidazo[4,5,1-de]acridin-6-ones with an (aminoalkyl)amino group in the side chain, has been made. These compounds were synthesized by reduction of 1-substituted 4-nitroacridin-9(10H)-ones and subsequent reaction of the derived amines with carboxylic acids. Their cytotoxic activity against HeLaS3 cells in tissue culture and in vivo antitumor activity against P388 leukemia in mice was demonstrated. A strict relationship between the antineoplastic activity and the number of methylene spacers between proximal and distal nitrogens in the side chain was established.

PMID:
2296035
DOI:
10.1021/jm00163a009
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center