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J Insect Physiol. 2013 Feb;59(2):138-47. doi: 10.1016/j.jinsphys.2012.08.015. Epub 2012 Sep 5.

The roles of serpins in mosquito immunology and physiology.

Author information

1
Kansas State University, Division of Biology, Manhattan, KS 66506, USA. mmg@ksu.edu

Abstract

In vector-borne diseases, the complex interplay between pathogen and its vector's immune system determines the outcome of infection and therefore disease transmission. Serpins have been shown in many animals to be key regulators of innate immune reactions. Their control over regulatory proteolytic cascades ultimately decides whether the recognition of a pathogen will lead to an appropriate immune response. In mosquitoes, serpins (SRPNs) regulate the activation of prophenoloxidase and thus melanization, contribute to malaria parasite lysis, and likely Toll pathway activation. Additionally, in culicine mosquitoes, SRPNs are able to regulate hemostasis in the vertebrate host, suggesting a crucial role during bloodfeeding. This review summarizes the annotation, transcriptional regulation, and current knowledge of SRPN function in the three mosquito species for which the complete genome sequence is available. Additionally, we give a brief overview of how SRPNs may be used to prevent transmission of vector-borne diseases.

PMID:
22960307
PMCID:
PMC3560325
DOI:
10.1016/j.jinsphys.2012.08.015
[Indexed for MEDLINE]
Free PMC Article

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