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Dev Biol. 2012 Nov 15;371(2):246-55. doi: 10.1016/j.ydbio.2012.08.016. Epub 2012 Aug 30.

Wnt signaling though beta-catenin is required for prostate lineage specification.

Author information

1
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. simons@jhmi.edu

Abstract

Androgens initiate a complex network of signals within the UGS that trigger prostate lineage commitment and bud formation. Given its contributions to organogenesis in other systems, we investigated a role for canonical Wnt signaling in prostate development. We developed a new method to achieve complete deletion of beta-catenin, the transcriptional coactivator required for canonical Wnt signaling, in early prostate development. Beta-catenin deletion abrogated canonical Wnt signaling and yielded prostate rudiments that exhibited dramatically decreased budding and failed to adopt prostatic identity. This requirement for canonical Wnt signaling was limited to a brief critical period during the initial molecular phase of prostate identity specification. Deletion of beta-catenin in the adult prostate did not significantly affect organ homeostasis. Collectively, these data establish that beta-catenin and Wnt signaling play key roles in prostate lineage specification and bud outgrowth.

PMID:
22960283
PMCID:
PMC3472417
DOI:
10.1016/j.ydbio.2012.08.016
[Indexed for MEDLINE]
Free PMC Article

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