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Immunity. 2012 Sep 21;37(3):524-34. doi: 10.1016/j.immuni.2012.06.011. Epub 2012 Sep 6.

γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.

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1
Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Abstract

γδ T cells contribute uniquely to immune competence. Nevertheless, how they function remains an enigma. It is unclear what most γδ T cells recognize, what is required for them to mount an immune response, and how the γδ T cell response is integrated into host immune defense. Here, we report that a noted B cell antigen, the algae protein phycoerythrin (PE), is a murine and human γδ T cell antigen. Employing this specificity, we demonstrated that antigen recognition activated naive γδ T cells to make interleukin-17 and respond to cytokine signals that perpetuate the response. High frequencies of antigen-specific γδ T cells in naive animals and their ability to mount effector response without extensive clonal expansion allow γδ T cells to initiate a swift, substantial response. These results underscore the adaptability of lymphocyte antigen receptors and suggest an antigen-driven rapid response in protective immunity prior to the maturation of classical adaptive immunity.

PMID:
22960222
PMCID:
PMC3495981
DOI:
10.1016/j.immuni.2012.06.011
[Indexed for MEDLINE]
Free PMC Article
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