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Food Chem Toxicol. 2012 Dec;50(12):4239-45. doi: 10.1016/j.fct.2012.08.047. Epub 2012 Aug 31.

Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats.

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1
Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Republic of Korea.

Abstract

Fruits of Schisandra have been traditionally used in East Asia for the treatment of dyspnea, cough, dysentery, insomnia, tonic-clonic seizures, and amnesia. Schisandrin B, a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver and heart. In the present study, we investigated the neuroprotective effects of Schisandrin B, a constituent drug of the fruit of Schisandra, against focal cerebral ischemia in rats. Schisandrin B (10, 30 mg/kg, i.p.) was twice administered 30 min before the onset of ischemia and 2h after reperfusion. Schisandrin B 10 and 30 mg/kg treated groups showed infarct volumes reduced by 25.7% and 53.4%, respectively, 2h after occlusion. Also, Schisandrin B treated animal treatment abrogated protein expression of TNF-α and IL-1β and degradation of MMP-2 and MMP-9 in ischemic hemispheres. These results suggest that Schisandrin B treatment provides a neuroprotective effect to rats after transient focal cerebral ischemia by inhibiting inflammation and by protecting against metalloproteinase degradation.

PMID:
22960133
DOI:
10.1016/j.fct.2012.08.047
[Indexed for MEDLINE]
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