Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2012 Oct 1;22(19):6301-5. doi: 10.1016/j.bmcl.2012.06.067. Epub 2012 Jun 28.

Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitors.

Author information

1
Zhejiang Betapharma, 589 Hongfong Rd., YuhangDistrict, Zhejiang 311100, PR China. shaojing.hu@betapharma.com.cn

Abstract

Crown ether fused anilinoquinazoline analogues were synthesized as novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. Representative compounds showed potent and selective EGFR inhibitory activities in an in vitro EGFR kinase assay and an EGFR-mediated intracellular tyrosine phosphorylation assay. The synthesis and preliminary biological, physical, and pharmacokinetic evaluation of these fused quinazoline compounds is reported.

PMID:
22959248
DOI:
10.1016/j.bmcl.2012.06.067
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center