Format

Send to

Choose Destination
Cell Stem Cell. 2012 Sep 7;11(3):302-17. doi: 10.1016/j.stem.2012.08.006.

Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.

Author information

1
Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Hematopoietic stem cells (HSCs) represent one of the first recognized somatic stem cell types. As such, nearly 200 genes have been examined for roles in HSC function in knockout mice. In this review, we compile the majority of these reports to provide a broad overview of the functional modules revealed by these genetic analyses and highlight some key regulatory pathways involved, including cell cycle control, Tgf-β signaling, Pten/Akt signaling, Wnt signaling, and cytokine signaling. Finally, we propose recommendations for characterization of HSC function in knockout mice to facilitate cross-study comparisons that would generate a more cohesive picture of HSC biology.

PMID:
22958929
PMCID:
PMC3461270
DOI:
10.1016/j.stem.2012.08.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center