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Neuron. 2012 Sep 6;75(5):739-42. doi: 10.1016/j.neuron.2012.08.008.

Deterministic or stochastic choices in retinal neuron specification.

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Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA.


There are two views on vertebrate retinogenesis: a deterministic model dependent on fixed lineages and a stochastic model in which choices of division modes and cell fates cannot be predicted. In this issue of Neuron, He et al. (2012) address this question in zebrafish using live imaging and mathematical modeling.

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