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Hypertens Pregnancy. 2013;32(1):32-41. doi: 10.3109/10641955.2012.697952. Epub 2012 Sep 7.

Effect of L-arginine supplementation on blood pressure in pregnant women: a meta-analysis of placebo-controlled trials.

Author information

1
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, PR China.

Abstract

OBJECTIVE:

A meta-analysis of placebo-controlled trials was conducted to evaluate the effect of L-arginine supplementation on blood pressure (BP) in pregnancy.

METHODS:

Trials were searched in PubMed, Embase, and Cochrane Library. A total of five trials were included in the meta-analysis.

RESULTS:

L-arginine supplementation exhibited a mean decrease of 3.07 mmHg (p = 0.004) for diastolic blood pressure and a mean increase of 1.23 weeks (p = 0.002) for gestation age at delivery in pregnancy, but did not reduce systolic BP (p = 0.19) as compared to placebo.

CONCLUSION:

L-arginine supplementation had a significant effect of lowering diastolic blood pressure and prolonging gestation age in pregnancy.

PMID:
22957482
DOI:
10.3109/10641955.2012.697952
[Indexed for MEDLINE]

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