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Eur Rev Med Pharmacol Sci. 2012 Jul;16 Suppl 3:121-5.

Anti-inflammatory effects of Hylomecon hylomeconoides in RAW 264.7 cells.

Author information

1
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang, Republic of Korea.

Abstract

BACKGROUND AND OBJECTIVES:

Papaveraceae serve as a rich source of various alkaloids which have anti-inflammatory effect.

MATERIALS AND METHODS:

In this study, we investigated the effect of Hylomecon hylomeconoides ethanol extract (HHE) on lipopolysaccharide (LPS)-induced NO and interleukin-6 (IL-6) production in RAW 264.7 cells.

RESULTS:

HHE inhibited LPS-induced NO and IL-6 production. Moreover, HHE suppressed the phosphorylation of ERK1/2 and p38 in LPS-induced RAW 264.7 in a dose-dependent manner. Furthermore, major constituents, dihydrosanguinarine and 6-methoxydihydrosanguinarine, of the chloroform-soluble extract were analyzed.

CONCLUSIONS:

Taken together, the results of this study indicate that the anti-inflammatory effects of HHE may occur via the inhibition of NO and IL-6 expression through the down-regulation of MAP kinase (ERK1/2, p38) phosphorylation in RAW 264.7 cells.

PMID:
22957426
[Indexed for MEDLINE]

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