Abstract
Noni juice (NJ) is rich in phytochemicals and polysaccharides. Lipid-lowering and antioxidative effects of NJ were investigated in this study. Fifty male hamsters were assigned randomly to one of the following groups: (1) normal diet and distilled water (LFCD); (2) high-fat/cholesterol diet and distilled water (HFCD); (3) HFCD and 3 ml NJ (including 0.20 g solids)/kg BW (NJ_L); (4) HFCD and 6 mL NJ (including 0.40 g solids)/kg BW (NJ_M); (5) HFCD and 9 ml NJ (including 0.60 g solids)/kg BW (NJ_H) for six weeks. NJ supplementation decreased (p < 0.05) serum triacylglycerol, cholesterol, atherogenic index, malondialdehyde levels, and hepatic lipids in HFCD hamsters, whereas serum trolox equivalent antioxidant capacity, glutathione, and fecal lipids in HFCD hamsters were increased (p < 0.05) by NJ supplementation. Although NJ supplementation downregulated (p < 0.05) sterol regulator element binding protein-1c in HFCD hamsters, it upregulated (p < 0.05) hepatic peroxisome proliferator-activated receptor-alpha and uncoupling protein 2 gene expressions in HFCD hamsters. Results demonstrate that NJ promotes cardioprotection in a high-fat/cholesterol diet.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / metabolism
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Antioxidants / pharmacology
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Antioxidants / therapeutic use*
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Atherosclerosis / prevention & control
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Beverages
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Cholesterol, Dietary / blood
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Cricetinae
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Diet, High-Fat*
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Dietary Fats / blood
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Dietary Supplements
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Feces / chemistry
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Fruit
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Gene Expression / drug effects
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Glutathione / blood
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Hypolipidemic Agents / pharmacology
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Hypolipidemic Agents / therapeutic use*
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Ion Channels / genetics
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Ion Channels / metabolism
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Lipid Metabolism / drug effects*
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Liver / metabolism
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Male
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Malondialdehyde / metabolism
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Mitochondrial Proteins / genetics
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Mitochondrial Proteins / metabolism
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Morinda / chemistry*
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PPAR alpha / genetics
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PPAR alpha / metabolism
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Phytotherapy*
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Plant Preparations / pharmacology
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Plant Preparations / therapeutic use*
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Polysaccharides / pharmacology
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Polysaccharides / therapeutic use
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Random Allocation
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Sterol Regulatory Element Binding Protein 1 / metabolism
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Triglycerides / blood
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Uncoupling Protein 2
Substances
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Antioxidants
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Cholesterol, Dietary
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Dietary Fats
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Hypolipidemic Agents
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Ion Channels
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Mitochondrial Proteins
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PPAR alpha
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Plant Preparations
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Polysaccharides
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Sterol Regulatory Element Binding Protein 1
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Triglycerides
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Uncoupling Protein 2
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Malondialdehyde
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Glutathione