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Cell Oncol (Dordr). 2012 Oct;35(5):317-34. Epub 2012 Sep 7.

Aberrant microRNA expression and its implications in the pathogenesis of leukemias.

Author information

1
Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, 1411713116, Tehran, Iran. sadegh.babashah@gmail.com

Abstract

BACKGROUND:

MicroRNAs (miRNAs) are a class of non-coding, endogenous, small RNAs that negatively regulate gene expression by inducing degradation or translational inhibition of target mRNAs. Aberrant expression of miRNAs appears to be a common characteristic of hematological malignancies including leukemias.

AIM:

Here we review the available data supporting a role of aberrant expression of miRNAs in the pathogenesis of leukemias including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and chronic lymphocytic leukemia (CLL).

CONCLUSIONS:

The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis, and therapy of leukemia. Since miRNAs can function as either oncogenes or tumor suppressor genes in leukemogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for leukemia therapy by either inhibiting or augmenting their activity.

PMID:
22956261
DOI:
10.1007/s13402-012-0095-3
[Indexed for MEDLINE]

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