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Nat Rev Immunol. 2012 Oct;12(10):721-8. doi: 10.1038/nri3294. Epub 2012 Sep 7.

Unconventional recognition of peptides by T cells and the implications for autoimmunity.

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Washington University School of Medicine, Department of Pathology and Immunology, St Louis, Missouri 63110, USA.


The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide-MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune response to proteins. Importantly, these unconventional T cells can be found in the setting of autoimmunity. Here, we discuss unconventional peptide recognition by type B T cells and consider the implications for type 1 diabetes and other autoimmune diseases.

[Indexed for MEDLINE]

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