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Science. 2012 Sep 7;337(6099):1186-9. doi: 10.1126/science.1223539.

How cells know the size of their organelles.

Author information

  • 1Department of Biochemistry and Biophysics, UCSF Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA. yhmchan@ucsf.edu

Abstract

Cells have developed ways to sense and control the size of their organelles. Size-sensing mechanisms range from direct measurements provided by dedicated reporters to indirect functional readouts, and they are used to modify organelle size under both normal and stress conditions. Organelle size can also be controlled in the absence of an identifiable size sensor. Studies on flagella have dissected principles of size sensing and control, and it will be exciting to see how these principles apply to other organelles.

PMID:
22955827
PMCID:
PMC3625396
DOI:
10.1126/science.1223539
[PubMed - indexed for MEDLINE]
Free PMC Article
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