Chronic eyelid swelling as an initial manifestation of myeloma-associated amyloidosis

Ophthalmic Plast Reconstr Surg. 2013 Jan-Feb;29(1):e12-4. doi: 10.1097/IOP.0b013e318259af06.

Abstract

Orbital amyloidosis is uncommon and difficult to diagnose due to their variable clinical presentations. The authors report a case of a patient who presents with chronic eyelid swelling as an initial manifestation of myeloma-associated amyloidosis. This patient was also found to have retrobulbar infiltration with no visual impairment. The authors also describe the first documentation of the atypical necrotic appearance of amyloidosis in the involved eyelid tissues. Myeloma-associated amyloidosis can present as chronic, nonspecific periorbital swelling, hence a biopsy of the affected tissues is important in preventing a delay in the correct diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Amyloidosis / diagnosis*
  • Amyloidosis / therapy
  • Biopsy
  • Blepharoplasty
  • Combined Modality Therapy
  • Cyclophosphamide
  • Drug Therapy, Combination
  • Edema / diagnosis*
  • Edema / therapy
  • Eyelid Diseases / diagnosis*
  • Eyelid Diseases / therapy
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Myeloma / diagnosis*
  • Multiple Myeloma / therapy
  • Prednisolone / therapeutic use
  • Stem Cell Transplantation
  • Thalidomide / therapeutic use
  • Tomography, X-Ray Computed
  • Transplantation, Autologous

Substances

  • Glucocorticoids
  • Immunosuppressive Agents
  • Thalidomide
  • Cyclophosphamide
  • Prednisolone