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J Epidemiol. 2012;22(6):508-16. Epub 2012 Sep 1.

Incidence and short-term mortality from perforated peptic ulcer in Korea: a population-based study.

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1
Health Insurance Review and Assessment Service, Research and Development Center, Seoul, South Korea.

Abstract

BACKGROUND:

Perforated peptic ulcer (PPU) is associated with serious health and economic outcomes. However, few studies have estimated the incidence and health outcomes of PPU using a nationally representative sample in Asia. We estimated age- and sex-specific incidence and short-term mortality from PPU among Koreans and investigated the risk factors for mortality associated with PPU development.

METHODS:

A retrospective population-based study was conducted from 2006 through 2007 using the Korean National Health Insurance claims database. A diagnostic algorithm was derived and validated to identify PPU patients, and PPU incidence rates and 30-day mortality rates were determined.

RESULTS:

From 2006 through 2007, the PPU incidence rate per 100 000 population was 4.4; incidence among men (7.53) was approximately 6 times that among women (1.24). Incidence significantly increased with advanced age, especially among women older than 50 years. Among 4258 PPU patients, 135 (3.15%) died within 30 days of the PPU event. The 30-day mortality rate increased with advanced age and reached almost 20% for patients older than 80 years. The 30-day mortality rate was 10% for women and 2% for men. Older age, being female, and higher comorbidity were independently associated with 30-day mortality rate among PPU patients in Korea.

CONCLUSIONS:

Special attention should be paid to elderly women with high comorbidity who develop PPU.

PMID:
22955110
PMCID:
PMC3798562
[Indexed for MEDLINE]
Free PMC Article

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