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Curr Opin Rheumatol. 2012 Nov;24(6):602-8.

Myositis autoantibodies.

Author information

1
Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21224, USA.

Abstract

PURPOSE OF REVIEW:

To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies.

RECENT FINDINGS:

Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype. Autoantibodies found in patients with autoimmune necrotizing myopathies recognize signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzime A reductase (HMG-CoA) reductase. The latter are found in patients with statin-associated autoimmune muscle disease.

SUMMARY:

As these are helpful both diagnostically and prognostically, a rheumatologist should be familiar with autoantibodies found in patients with dermatomyositis and the autoimmune necrotizing myopathies.

PMID:
22955022
PMCID:
PMC3874450
DOI:
10.1097/BOR.0b013e328358bd85
[Indexed for MEDLINE]
Free PMC Article
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