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Fitoterapia. 2012 Dec;83(8):1484-8. doi: 10.1016/j.fitote.2012.08.014. Epub 2012 Aug 29.

Anti-inflammatory constituents from Tabebuia avellanedae.

Author information

1
Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. suomaorong@163.com

Abstract

Five novel compounds were isolated from the water extract of Tabebuia avellanedae, and their structures were established by analysis of NMR spectroscopy and mass spectrometry. Compounds 1-5 at 25μM showed strong inhibitory activity on the inflammatory cytokine, tumor-necrosis factor-α and interleukin-1β production in cultured human myeloma THP-1 cells co-stimulated with lipopolysaccharide without any significant cytotoxicity, and their anti-allergic and antioxidant activities were evaluated.

PMID:
22955001
DOI:
10.1016/j.fitote.2012.08.014
[Indexed for MEDLINE]

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