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Bioarchitecture. 2012 Sep-Oct;2(5):158-70. doi: 10.4161/bioa.21791. Epub 2012 Sep 1.

Myosins in cell junctions.

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1
Department of Cell and Molecular Physiology; School of Medicine; University of North Carolina at Chapel Hill; Chapel Hill, NC USA.

Abstract

The development of cell-cell junctions was a fundamental step in metazoan evolution, and human health depends on the formation and function of cell junctions. Although it has long been known that actin and conventional myosin have important roles in cell junctions, research has begun to reveal the specific functions of the different forms of conventional myosin. Exciting new data also reveals that a growing number of unconventional myosins have important roles in cell junctions. Experiments showing that cell junctions act as mechanosensors have also provided new impetus to understand the functions of myosins and the forces they exert. In this review we will summarize recent developments on the roles of myosins in cell junctions.

KEYWORDS:

Myo10; Myo15a; Myo1e; Myo6; Myo7a; Myo9a; Myo9b; adherens junction; dachs; myosin; nonmuscle myosin; tight junction

PMID:
22954512
PMCID:
PMC3696060
DOI:
10.4161/bioa.21791
[Indexed for MEDLINE]
Free PMC Article
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