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Food Chem. 2012 Dec 1;135(3):2029-34. doi: 10.1016/j.foodchem.2012.06.090. Epub 2012 Jul 1.

Antimutagenic and antioxidant activity of Lisosan G in Saccharomyces cerevisiae.

Author information

1
National Research Council, Institute of Biology and Agricultural Biotechnology (IBBA), Pisa Unit, Research Area of Pisa, Via Moruzzi 1, 56124 Pisa, Italy. frassinetti@ibba.cnr.it

Abstract

In the present study the antimutagenic and antioxidant effects of a powder of grain (Lisosan G) in yeast Saccharomyces cerevisiae were studied. Results showed that Lisosan G treatment decreased significantly the intracellular ROS concentration and mutagenesis induced by hydrogen peroxide in S. cerevisiae D7 strain. The effect of Lisosan G was then evaluated by using superoxide dismutase (SOD) proficient and deficient strains of S. cerevisiae. Lisosan G showed protective activity in sod1Δ and sod2Δ mutant strains, indicating an in vivo antioxidant effect. A high radical scavenging activity of Lisosan G was also demonstrated in vitro using the oxygen radical absorbance capacity (ORAC) assay. The obtained results showed a protective effect of Lisosan G in yeast cells, indicating that its antioxidant capacity contributes to its antimutagenic action.

PMID:
22953954
DOI:
10.1016/j.foodchem.2012.06.090
[Indexed for MEDLINE]

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