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Iran J Psychiatry. 2012 Spring;7(2):87-92.

Melatonin effects in methylphenidate treated children with attention deficit hyperactivity disorder: a randomized double blind clinical trial.

Author information

1
Psychiatry and Psychology Research Center,Tehran University of Medical Sciences, Tehran, Iran.

Abstract

OBJECTIVE:

The aim of this study was to determine melatonin effects on sleep patterns, symptoms of hyperactivity and attention deficiency in children with attention-deficit hyperactivity disorder (ADHD).

METHODS:

Children with age range of 7-12 years who had a combined form of ADHD were randomly divided in to 2 groups according to gender blocks. One group took melatonin (3 or 6mg) combined with methylphenidate (Ritalin) (1mg/kg), and the other group took placebo combined with methylphenidate (1mg/kg). ADHD rating scale and sleep patterns questionnaires were completed. Research hypotheses were assessed at the baseline, the second, fourth and eighth weeks after the treatment.

RESULTS:

The mean sleep latency and total sleep disturbance scores were reduced in melatonin group, while the scores increased in the placebo group (p≥0.05). Data analysis, using ANOVA with repeated measures, did not show any statistically significant differences between the two groups in ADHD scores.

CONCLUSION:

Administration of melatonin along with methylphenidate can partially improve symptoms of sleep disturbance. However, it does not seem to reduce attention deficiency and hyperactivity behavior of children with ADHD.

KEYWORDS:

Attention deficit disorder with hyperactivity Disorder; Child; Melatonin; Methylphenidate; Sleep

PMID:
22952551
PMCID:
PMC3428643
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