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Case Rep Med. 2012;2012:387140. doi: 10.1155/2012/387140. Epub 2012 Aug 16.

Vitiligo in a Patient Treated with Interferon Alpha-2a for Behçet's Disease.

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Ophthalmology Clinic, Umraniye Research and Education Hospital, Adem Yavuz Caddesi, Ümraniye, İstanbul, Turkey.


Behçet's disease (BD) and vitiligo are diseases of unknown etiology. Interferon (IFN) alpha therapy is commonly used in Behçet uveitis. Interferon treatment in various diseases have also been observed causing certain autoimmune diseases such as vitiligo because of its immunomodulatory activity. The association between IFN therapy and vitiligo has been reported in the literature. We report a 21-year-old man with BD in whom vitiligo occurred during IFN treatment. To the best of our knowledge, this is the first reported case of such an association.

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