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Angew Chem Int Ed Engl. 2012 Sep 24;51(39):9818-21. doi: 10.1002/anie.201206059. Epub 2012 Sep 5.

In vivo fluorescence imaging with Ag2S quantum dots in the second near-infrared region.

Author information

1
Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

Abstract

Hits the dot: Ag(2)S quantum dots (QDs) with bright near-infrared-II fluorescence emission (around 1200 nm) and six-arm branched PEG surface coating were synthesized for in vivo small-animal imaging. The 6PEG-Ag(2)S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half-life of approximately 4 h. Clearance of the injected 6PEG-Ag(2)S QDs occurs mainly through the biliary pathway in mice.

PMID:
22951900
DOI:
10.1002/anie.201206059
[Indexed for MEDLINE]

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