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Chem Commun (Camb). 2012 Oct 14;48(80):10034-6. doi: 10.1039/c2cc34498j.

A strategy to enhance the binding affinity of fluorophore-aptamer pairs for RNA tagging with neomycin conjugation.

Author information

1
Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, California 94305-5484, USA.

Abstract

Fluorogenic sulforhodamine-neomycin conjugates have been designed and synthesized for RNA tagging. Conjugates were fluorescently activated by binding to RNA aptamers and exhibited greater than 250-400 fold enhancement in binding affinity relative to corresponding unconjugated fluorophores.

PMID:
22951899
PMCID:
PMC3728288
DOI:
10.1039/c2cc34498j
[Indexed for MEDLINE]
Free PMC Article
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