Format

Send to

Choose Destination
See comment in PubMed Commons below
J Invest Dermatol. 2013 Jan;133(1):128-34. doi: 10.1038/jid.2012.271. Epub 2012 Sep 6.

Linkage analysis of extended high-risk pedigrees replicates a cutaneous malignant melanoma predisposition locus on chromosome 9q21.

Author information

1
Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA. lisa.albright@utah.edu

Abstract

Three predisposition genes have been identified for cutaneous malignant melanoma (CMM), but they account for only ∼25% of melanoma clusters/pedigrees. Linkage analyses of melanoma pedigrees from many countries have failed to identify significant linkage evidence for the remaining predisposition genes that must exist. The Utah linkage analysis approach of using singly informative extended high-risk pedigrees combined with high-density single-nucleotide polymorphism (SNP) markers has successfully identified significant linkage evidence for two regions. This is, to our knowledge, the first genome-wide linkage analysis of the extended Utah high-risk CMM pedigrees, and it provides confirmation of linkage for a chromosome 9q region previously reported in Danish pedigrees. This report confirms that linkage analysis for common disorders can be successful in analysis of high-density markers in sets of singly informative high-risk pedigrees.

PMID:
22951724
PMCID:
PMC3535071
DOI:
10.1038/jid.2012.271
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center