Format

Send to

Choose Destination
See comment in PubMed Commons below
J Vasc Interv Radiol. 2012 Oct;23(10):1302-8. doi: 10.1016/j.jvir.2012.07.010. Epub 2012 Aug 28.

Clinical improvement after extracranial venoplasty in multiple sclerosis.

Author information

1
Applied fMRI Institute, Hubbard Foundation, San Diego, California 92064, USA. davidhubbardmd@gmail.com

Abstract

PURPOSE:

This study proposed to prospectively evaluate safety and clinical changes in outpatient endovascular treatment in patients with multiple sclerosis (MS) and chronic cerebrospinal venous insufficiency (CCSVI).

MATERIALS AND METHODS:

Two hundred fifty-nine patients with MS were followed with the Multiple Sclerosis Impact Scale (MSIS-29) before and for 1 and 6 months after treatment of extracranial internal jugular vein and azygos vein stenoses and occlusions using venous angioplasty, as well as stent placement in 2.5% of patients. Before treatment, the patients were tested with magnetic resonance (MR) venography and flow quantification.

RESULTS:

We found statistically significant improvements in the MSIS-29 scores (P < .01) at both 1 and 6 months. At 1 and 6 months, 67.9% and 53.6% were improved on the physical scale, respectively, and 53.0% and 44.4% were improved on the psychological scale, respectively. Women showed greater improvement than did men on the physical scale at 6 months (P = .01). Patients with primary progressive MS (PPMS) showed less improvement than did those with relapsing-remitting MS (RRMS) on the psychological scale at 1 month, and venoplasty treatment of more vein sites versus fewer vein sites showed greater improvement on the physical scale at both 1 and 6 months. Fifteen patients (6.3%) reported recurrent symptoms after clinical improvement and were treated again. There was one serious adverse event, a deep venous thrombosis at the catheter insertion site, which resolved with treatment.

CONCLUSIONS:

Endovascular treatment of CCSVI in patients with MS appears to be a safe procedure resulting in significant clinical improvement.

PMID:
22951366
DOI:
10.1016/j.jvir.2012.07.010
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center