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Dan Med J. 2012 Sep;59(9):A4505.

Vitamin D deficiency is unrelated to type of atrial fibrillation and its complications.

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1
Department of Cardiology, Hvidovre Hospital.

Abstract

INTRODUCTION:

Vitamin D plays an important role in a broad range of organ functions, including the cardiovascular system. Only one study has tested the association between vitamin D deficiency and arrhythmia and it found no association. The aim of the present study was to evaluate the association between vitamin D deficiency and the type of atrial fibrillation (AF) and complications to AF.

MATERIAL AND METHODS:

In total, 258 patients were consecutively included from March 2009 to February 2011. All in- and out-patients in the Department of Cardiology at Hvidovre Hospital were invited to participate, provided they had electrocardiographically documented AF. Patients with dementia or terminal illness were excluded. 25 hydroxyvitamin D (25 OHD) was measured with a chemiluminescence assay (Liaison from DiaSorin, Stillwater, Minnesota, USA).

RESULTS:

No association between vitamin D level and type of AF was found. Furthermore, no association between vitamin D deficiency and ischaemic heart disease, stroke or acute myocardial infarction was found. Vitamin D deficiency was significantly associated with low age (p = 0.02) and gender with a higher proportion of females having the optimal level of 25 OHD (p = 0.0005).

CONCLUSION:

Other studies have found a beneficial effect of vitamin D on cardiovascular diseases, but we found no association between vitamin D deficiency and the type of AF or complications to AF. Further investigation is necessary to determine whether vitamin D supplementation improves cardiovascular outcomes in patients with AF.

FUNDING:

The study has received financial support from several private and one public fund.

TRIAL REGISTRATION:

The study was approved by the National Ethics Committee (Project-ID: H-C-2009-014).

PMID:
22951200
[Indexed for MEDLINE]
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