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Trends Cell Biol. 2012 Nov;22(11):592-601. doi: 10.1016/j.tcb.2012.08.002. Epub 2012 Aug 30.

Redox control of cell proliferation.

Author information

1
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

Abstract

Cell proliferation is regulated by multiple signaling pathways and stress surveillance systems to ensure cell division takes place with fidelity. In response to oxidative stress, cells arrest in the cell-cycle and aberrant redox control of proliferation underlies the pathogenesis of many diseases including cancer and neurodegenerative disorders. Redox sensing of cell-cycle regulation has recently been shown to involve reactive cysteine thiols that function as redox sensors in cell-cycle regulators. By modulating cell-cycle regulators these redox-active thiols ensure cell division is executed at the right redox environment. This review summarizes recent findings on regulation of cell division by the oxidation of cysteines in cell division regulators and the potential of targeting these critical cysteine residues for cancer therapy.

PMID:
22951073
DOI:
10.1016/j.tcb.2012.08.002
[Indexed for MEDLINE]

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